Title : New evidence of H1-receptor independent COX-2 inhibition by fexofenadine HCl in vitro.

Pub. Date : 2006

PMID : 17016062






4 Functional Relationships(s)
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1 New evidence of H1-receptor independent COX-2 inhibition by fexofenadine HCl in vitro. fexofenadine mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 The inhibition of COX-2 activity by FEX was similar to that seen with the selective COX-2 inhibitor, DuP-679. fexofenadine mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 CONCLUSION: FEX showed selective arachidonic acid-mediated COX-2 inhibitory enzyme activity, which differed markedly from the COX inhibitory enzyme activity of LOR. fexofenadine mitochondrially encoded cytochrome c oxidase II Homo sapiens
4 This selective COX-2 inhibitor activity by FEX may contribute to its anti-inflammatory properties in relieving nasal congestion in allergic rhinitis. fexofenadine mitochondrially encoded cytochrome c oxidase II Homo sapiens