Title : Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types.

Pub. Date : 2007 Jan

PMID : 17012310






1 Functional Relationships(s)
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Protein Name
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1 Two of three types of nonnaturally occurring atypical oligosaccharide IgG1, except the complex type, reduced the affinity for both human lymphocyte receptor IIIa (FcgammaRIIIa) and the C1q component of the complement, resulting in reduction of ADCC and CDC. Oligosaccharides Fc gamma receptor IIIa Homo sapiens