Pub. Date : 1990 Dec 1
PMID : 1700998
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PAF (10 nM to 1 microM) caused a concentration-dependent, noncytotoxic histamine release (greater than or equal to 10% of total) in 27 of 44 subjects tested (24 atopic and 20 nonatopic donors). | Histamine | PCNA clamp associated factor | Homo sapiens |
| 2 | Coincubation of PAF with cytochalasin B (5 micrograms/ml) enhanced the release of histamine induced by PAF and activated the release process in most donors (42 of 44). | Histamine | PCNA clamp associated factor | Homo sapiens |
| 3 | Coincubation of PAF with cytochalasin B (5 micrograms/ml) enhanced the release of histamine induced by PAF and activated the release process in most donors (42 of 44). | Histamine | PCNA clamp associated factor | Homo sapiens |
| 4 | The release of histamine activated by PAF was inhibited by the specific PAF receptor antagonist, L-652,731, with an IC50 of 0.4 microM. | Histamine | PCNA clamp associated factor | Homo sapiens |
| 5 | The release of histamine activated by PAF was inhibited by the specific PAF receptor antagonist, L-652,731, with an IC50 of 0.4 microM. | Histamine | PCNA clamp associated factor | Homo sapiens |
| 6 | If neutrophils were removed from the basophil preparation by a Percoll gradient or a countercurrent elutriation technique, there was a significant decrease in PAF-induced histamine release. | Histamine | PCNA clamp associated factor | Homo sapiens |
| 7 | Finally, among human histamine-containing cells, the basophils are unique in degranulating following a PAF challenge. | Histamine | PCNA clamp associated factor | Homo sapiens |