Title : Study on effects of extracts from Salvia Miltiorrhiza and Curcuma Longa in inhibiting phosphorylated extracellular signal regulated kinase expression in rat's hepatic stellate cells.

Pub. Date : 2006 Sep

PMID : 17005083






2 Functional Relationships(s)
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1 Both SAB and curcumin showed insignificant effect on the ERK expression level, but they could significantly reduce the level of phosphorylated-ERK expression, showing significant difference as compared with that in the control group (P < 0.01 and P < 0.05 respectively). salvianolic acid B Eph receptor B1 Rattus norvegicus
2 CONCLUSION: SAB and curcumin could significantly inhibit the proliferation, activation of HSC, and the production of type I collagen in HSC, the mechanism may be associated with their inhibition on ERK phosphorylation. salvianolic acid B Eph receptor B1 Rattus norvegicus