Title : Human P450scc gene transcription is induced by cyclic AMP and repressed by 12-O-tetradecanoylphorbol-13-acetate and A23187 through independent cis elements.

Pub. Date : 1990 Nov

PMID : 1700277






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 In Y1 cells transfected with 2,327 base pairs of the human P450scc promoter fused to the bacterial gene for chloramphenicol acetyltransferase (CAT), forskolin increased CAT activity 900% while combined TPA plus A23187 reduced CAT activity to 15% of the control level. Colforsin cytochrome P450 family 11 subfamily A member 1 Homo sapiens
2 Forskolin induced the P450scc promoter as rapidly as a promoter containing two cAMP-responsive elements fused to a simian virus 40 promoter, a system known to respond directly to cAMP. Colforsin cytochrome P450 family 11 subfamily A member 1 Homo sapiens