Pub. Date : 2006 Nov 30
PMID : 16999939
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have attempted to unravel the signal transduction pathways involved in elevated COX-2 expression in mouse skin stimulated with a prototype tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and its modulation by resveratrol, a phytoalexin known to exert potential chemopreventive effects. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Mus musculus |
| 2 | We have attempted to unravel the signal transduction pathways involved in elevated COX-2 expression in mouse skin stimulated with a prototype tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and its modulation by resveratrol, a phytoalexin known to exert potential chemopreventive effects. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Mus musculus |
| 3 | Our study revealed that topical application of TPA induced COX-2 expression in mouse skin via activation of nuclear factor-kappaB (NF-kappaB), which is regulated by upstream IkappaB kinase (IKK) or differentially by mitogen-activated protein (MAP) kinases. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Mus musculus |
| 4 | Besides NF-kappaB, the p38 MAP kinase-mediated activation of activator protein-1 (AP-1) has also been attributed to TPA-induced COX-2 expression in mouse skin. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Mus musculus |
| 5 | This commentary focuses on resveratrol modulation of intracellular signaling pathways involved in aberrant COX-2 expression in TPA-stimulated mouse skin to delineate molecular mechanisms underlying antitumor promoting effects of resveratrol. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Mus musculus |