Pub. Date : 2006 Jul
PMID : 16998541
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of insulin-like growth factor type-1 receptor is required for H2O2-induced PKB phosphorylation in vascular smooth muscle cells. | Hydrogen Peroxide | protein tyrosine kinase 2 beta | Homo sapiens |
| 2 | Previous work from our laboratory has indicated that exogenous hydrogen peroxide (H2O2) activates several signaling protein kinases, such as extracellular signal-regulated kinase 1 and 2 (ERK1/2) and protein kinase B (PKB) in A10 vascular smooth muscle cells (VSMC). | Hydrogen Peroxide | protein tyrosine kinase 2 beta | Homo sapiens |
| 3 | Previous work from our laboratory has indicated that exogenous hydrogen peroxide (H2O2) activates several signaling protein kinases, such as extracellular signal-regulated kinase 1 and 2 (ERK1/2) and protein kinase B (PKB) in A10 vascular smooth muscle cells (VSMC). | Hydrogen Peroxide | protein tyrosine kinase 2 beta | Homo sapiens |
| 4 | Previous work from our laboratory has indicated that exogenous hydrogen peroxide (H2O2) activates several signaling protein kinases, such as extracellular signal-regulated kinase 1 and 2 (ERK1/2) and protein kinase B (PKB) in A10 vascular smooth muscle cells (VSMC). | Hydrogen Peroxide | protein tyrosine kinase 2 beta | Homo sapiens |
| 5 | Previous work from our laboratory has indicated that exogenous hydrogen peroxide (H2O2) activates several signaling protein kinases, such as extracellular signal-regulated kinase 1 and 2 (ERK1/2) and protein kinase B (PKB) in A10 vascular smooth muscle cells (VSMC). | Hydrogen Peroxide | protein tyrosine kinase 2 beta | Homo sapiens |
| 6 | Although a role for epidermal growth factor receptor (EGFR) protein tyrosine kinase (PTK) in H2O2-induced ERK1/2 signaling has been suggested, the contribution of this PTK or other receptor or nonreceptor PTKs to PKB activation is not well defined in VSMC. | Hydrogen Peroxide | protein tyrosine kinase 2 beta | Homo sapiens |
| 7 | In this study, we used pharmacological inhibitors to investigate the role of receptor and Src-family-PTKs in H2O2-induced PKB phosphorylation. | Hydrogen Peroxide | protein tyrosine kinase 2 beta | Homo sapiens |
| 8 | Moreover, H2O2-induced PKB phosphorylation was associated with increased tyrosine phosphorylation of c-Src and Pyk2 in an AG1024- and PP2-inhibitable manner. | Hydrogen Peroxide | protein tyrosine kinase 2 beta | Homo sapiens |
| 9 | Moreover, H2O2-induced PKB phosphorylation was associated with increased tyrosine phosphorylation of c-Src and Pyk2 in an AG1024- and PP2-inhibitable manner. | Hydrogen Peroxide | protein tyrosine kinase 2 beta | Homo sapiens |
| 10 | In conclusion, these data provide evidence of the contribution of IGF-1R-PTK in initiating H2O2-evoked PKB phosphorylation in A10 VSMC, with an intermediary role for c-Src and Pyk2 in this process. | Hydrogen Peroxide | protein tyrosine kinase 2 beta | Homo sapiens |
| 11 | In conclusion, these data provide evidence of the contribution of IGF-1R-PTK in initiating H2O2-evoked PKB phosphorylation in A10 VSMC, with an intermediary role for c-Src and Pyk2 in this process. | Hydrogen Peroxide | protein tyrosine kinase 2 beta | Homo sapiens |
| 12 | In conclusion, these data provide evidence of the contribution of IGF-1R-PTK in initiating H2O2-evoked PKB phosphorylation in A10 VSMC, with an intermediary role for c-Src and Pyk2 in this process. | Hydrogen Peroxide | protein tyrosine kinase 2 beta | Homo sapiens |