Title : Metabolic engineering of the heterologous production of clorobiocin derivatives and elloramycin in Streptomyces coelicolor M512.

Pub. Date : 2006 Nov

PMID : 16996763






1 Functional Relationships(s)
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1 Introduction of plasmid pRHAM which contains four genes from the oleandomycin biosynthetic gene cluster, directing the synthesis of dTDP-rhamnose, led to a 26-fold increase of the production of glycosylated aminocoumarins. Aminocoumarins TAR DNA-binding protein-43 homolog Drosophila melanogaster