Title : Down-regulation of ABCB1 transporter by atorvastatin in a human hepatoma cell line and in human peripheral blood mononuclear cells.

Pub. Date : 2006 Dec

PMID : 16996216






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Correlation was found between ABCB1 mRNA levels and creatine kinase (r=0.30; p=0.014) and total cholesterol (r=-0.31; p=0.010). Cholesterol ATP binding cassette subfamily B member 1 Homo sapiens
2 ABCB1 plays a role in cellular protection as well as in secretion and/or disposition, therefore, inhibition of ABCB1 synthesis may increase the atorvastatin efficacy, leading to a more pronounced reduction of plasma cholesterol. Cholesterol ATP binding cassette subfamily B member 1 Homo sapiens
3 ABCB1 plays a role in cellular protection as well as in secretion and/or disposition, therefore, inhibition of ABCB1 synthesis may increase the atorvastatin efficacy, leading to a more pronounced reduction of plasma cholesterol. Cholesterol ATP binding cassette subfamily B member 1 Homo sapiens