Pub. Date : 2006 Dec
PMID : 16995874
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ZD6474 induced growth arrest and apoptosis of GIST-T1 cells in association with blockade of c-Kit and its downstream effectors, including Akt and extracellular signal-regulated kinase (ERK). | vandetanib | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | ZD6474 induced growth arrest and apoptosis of GIST-T1 cells in association with blockade of c-Kit and its downstream effectors, including Akt and extracellular signal-regulated kinase (ERK). | vandetanib | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | ZD6474 treatment also blocked the mammalian target of rapamycin (mTOR), which lies downstream of Akt and ERK. | vandetanib | mitogen-activated protein kinase 1 | Homo sapiens |