Title : Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles.

Pub. Date : 2006 Nov 10

PMID : 16989930






1 Functional Relationships(s)
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1 For the inhibition of hCYP51, IC(50) values split into two classes: the newer drugs fluconazole and itraconazole showed little inhibition (> or = 30 microM) while the older drugs were even more potent than the agricultural fungicides, with miconazole being the most potent (0.057 microM). Itraconazole cytochrome P450 family 51 subfamily A member 1 Homo sapiens