Title : Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver.

Pub. Date : 2006 Dec

PMID : 16988011






1 Functional Relationships(s)
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1 In this study, we showed in primary human hepatocytes that: 1) 5"-phosphoribosyl-5-aminoimidazol-4-carboxamide 1-beta-d-ribofuranoside and the biguanide metformin, known activators of AMPK, dose-dependently increase the expression of CYP2B6 and CYP3A4 to an extent similar to that of PB. Biguanides cytochrome P450 family 2 subfamily B member 6 Homo sapiens