Title : Rofecoxib is a potent, metabolism-dependent inhibitor of CYP1A2: implications for in vitro prediction of drug interactions.

Pub. Date : 2006 Dec

PMID : 16985100






1 Functional Relationships(s)
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1 Inactivation of CYP1A2 by rofecoxib required NADPH, and was characterized by a KI of 4.8 microM and a kinact of 0.07 min(-1). NADP cytochrome P450 family 1 subfamily A member 2 Homo sapiens