Title : The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions.

Pub. Date : 2006 Oct

PMID : 16980959






1 Functional Relationships(s)
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1 Here, we show that the hetero-oligomeric chaperonin TRiC (also known as CCT) physically interacts with polyglutamine-expanded variants of huntingtin (Htt) and effectively inhibits their aggregation. polyglutamine CCT Homo sapiens