Title : Suppressive effect of simvastatin on interferon-beta-induced expression of CC chemokine ligand 5 in microglia.

Pub. Date : 2006 Oct 30

PMID : 16978784






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The simvastatin treatment significantly diminished the microglial CCL5 expression induced by IFN-beta alone or by IFN-beta/TNF-alpha combination. Simvastatin tumor necrosis factor Homo sapiens
2 In the presence of simvastatin, the IFN-beta-induced activation of Janus kinase (Jak)-signal transducer and activator of transcription (STAT) pathway was attenuated, although this compound had little or no effect on the TNF-alpha-evoked activation of nuclear factor kappaB and c-Jun N-terminal kinase pathways. Simvastatin tumor necrosis factor Homo sapiens