Title : Critical role of the proline-rich region in Huntingtin for aggregation and cytotoxicity in yeast.

Pub. Date : 2006 Nov 24

PMID : 16973603






1 Functional Relationships(s)
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1 Strikingly, deletion of Hsp104 increases the size of inclusions formed by expanded poly(Q) lacking the proline-rich region and abolishes toxicity. polyglutamine chaperone ATPase HSP104 Saccharomyces cerevisiae S288C