Pub. Date : 2006 Oct
PMID : 16969513
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Paclitaxel and ceramide synergistically induce cell death with transient activation of EGFR and ERK pathway in pancreatic cancer cells. | Paclitaxel | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Furthermore, we observed that paclitaxel, ceramide, or combo-induced EGFR phosphorylation was inhibited by EGFR inhibitor, PD153035, while paclitaxel, ceramide, or combo-induced JNK and ERK phosphorylation was blocked by EGFR inhibitor, PD153035 and ERK inhibitor, U126. | Paclitaxel | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Furthermore, we observed that paclitaxel, ceramide, or combo-induced EGFR phosphorylation was inhibited by EGFR inhibitor, PD153035, while paclitaxel, ceramide, or combo-induced JNK and ERK phosphorylation was blocked by EGFR inhibitor, PD153035 and ERK inhibitor, U126. | Paclitaxel | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | EGFR and ERK inhibitors may further enhance the paclitaxel and ceramide effect. | Paclitaxel | mitogen-activated protein kinase 1 | Homo sapiens |