Title : Direct demonstration of an antiinflammatory effect of simvastatin in subjects with the metabolic syndrome.

Pub. Date : 2006 Nov

PMID : 16968805






1 Functional Relationships(s)
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1 Lovastatin significantly decreased Rho kinase and nuclear factor-kappaB activity, significantly increased Akt activity, and resulted in decreased monocyte IL-6 levels; these effects were reversed with mevalonate and geranylgeranyl pyrophosphate, indicating direct effects of statins on protein prenylation. Lovastatin AKT serine/threonine kinase 1 Homo sapiens