Title : Effects of pyrrophenone, an inhibitor of group IVA phospholipase A2, on eicosanoid and PAF biosynthesis in human neutrophils.

Pub. Date : 2006 Oct

PMID : 16967052






2 Functional Relationships(s)
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1 BACKGROUND AND PURPOSE: The biosynthesis of leukotrienes (LT) and platelet-activating factor (PAF) involves the release of their respective precursors, arachidonic acid (AA) and lyso-PAF by the group IVA PLA2 (cPLA2alpha). Leukotrienes PCNA clamp associated factor Homo sapiens
2 KEY RESULTS: Pyrrophenone potently inhibited LT, PGE2 and PAF biosynthesis in PMN with IC50s in the range of 1-20 nM. Leukotrienes PCNA clamp associated factor Homo sapiens