Pub. Date : 2006 Dec
PMID : 16966384
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It is reported that nicotine induces prostaglandinE2 (PGE(2)) production in PBMC through the up-regulation of cyclooxygenase (COX)-2 expression. | Nicotine | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | Consistent with this, we found that COX-2 and PKA inhibitors prevented the effects of nicotine on adhesion molecule expression and cytokine production, indicating that the mechanism of action of nicotine may be via endogenous PGE(2) production. | Nicotine | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | Consistent with this, we found that COX-2 and PKA inhibitors prevented the effects of nicotine on adhesion molecule expression and cytokine production, indicating that the mechanism of action of nicotine may be via endogenous PGE(2) production. | Nicotine | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |