Title : Exit from arsenite-induced mitotic arrest is p53 dependent.

Pub. Date : 2006 Sep

PMID : 16966095






1 Functional Relationships(s)
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1 Using a model cell line in which p53 expression is regulated exogenously in a tetracycline-off system (TR9-7 cells) , our laboratory has shown that arsenite disrupts mitosis and that p53-deficient cells [p53(-)], in contrast to p53-expressing cells [p53(+)], display greater sensitivity to arsenite-induced mitotic arrest and apoptosis. Tetracycline tumor protein p53 Homo sapiens