Pub. Date : 2006 Oct-Dec
PMID : 16964525
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Zn deficiency-triggered oxidative stress could affect cell signalling, including transcription factors containing Zn finger motifs and other oxidant-sensitive transcription factors such as nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1). | Zinc | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Zn deficiency-triggered oxidative stress could affect cell signalling, including transcription factors containing Zn finger motifs and other oxidant-sensitive transcription factors such as nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1). | Zinc | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Similarly, the cytosolic steps of the NF-kappaB cascade are activated by oxidants in Zn deficiency. | Zinc | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | We present here evidence that, following experimental depletion of Zn, both NF-kappaB and AP-1 signallings are altered in primary T cells isolated from young and elderly healthy individuals under CD3/CD28 costimulation. | Zinc | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | A supplementation of Zn restored both NF-kappaB and AP-1 activation in CD3/CD28 costimulated T cells from young, but not from elderly, healthy individuals, indicating that the Zn deficiency is only one component of a more complex mechanism involved in immunosenescence. | Zinc | nuclear factor kappa B subunit 1 | Homo sapiens |