Pub. Date : 2007 Feb
PMID : 16963224
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PKC delta phosphorylates p52ShcA at Ser29 to regulate ERK activation in response to H2O2. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | This phosphorylation is critical in H(2)O(2) induced ERK activation as reconstitution with ShcA Ser29A failed to rescue ERK activation of ShcA-/- MEFs, while ShcA could. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | In line with this conclusion, inhibition of PKC delta with inhibitors is able to diminish H(2)O(2) induced ERK activation in MEFs. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |