Title : Evaluation of monoquaternary pyridinium oximes potency to reactivate tabun-inhibited human acetylcholinesterase.

Pub. Date : 2007 Apr 20

PMID : 16962227






1 Functional Relationships(s)
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1 Final docked energies predicted correctly the relative order of the inhibition potency of compounds (except in the case of Py-4-CH(3)) as well as the most probable orientation of the best reactivator, Py-4-Br, which can result in an attack on the phosphorus atom of the tabun-phosphorylated human AChE. Phosphorus acetylcholinesterase (Cartwright blood group) Homo sapiens