Pub. Date : 2007 Jan
PMID : 16959946
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | IL-18 mediates the formation of stress-induced, histamine-dependent gastric lesions. | Histamine | interleukin 18 | Mus musculus |
| 2 | In IL-18 KO mice, the WRS-induced elevation of gastric HDC activity and histamine levels was much less than that in wild-type mice, but it was augmented by prior administration of IL-18. | Histamine | interleukin 18 | Mus musculus |
| 3 | In IL-18 KO mice, the WRS-induced elevation of gastric HDC activity and histamine levels was much less than that in wild-type mice, but it was augmented by prior administration of IL-18. | Histamine | interleukin 18 | Mus musculus |
| 4 | These results indicate that IL-18 is involved in the induction of gastric lesions by WRS through augmentation of HDC activity and production of histamine in the stomach. | Histamine | interleukin 18 | Mus musculus |