Title : Regulation of expression of the retinoic acid metabolizing enzyme CYP26A1 in uteri of ovariectomized mice after treatment with ovarian steroid hormones.

Pub. Date : 2007 Feb

PMID : 16955405






3 Functional Relationships(s)
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1 Regulation of expression of the retinoic acid metabolizing enzyme CYP26A1 in uteri of ovariectomized mice after treatment with ovarian steroid hormones. Tretinoin cytochrome P450, family 26, subfamily a, polypeptide 1 Mus musculus
2 In this study, we determined the influence of progesterone and 17-ss-estradiol on the uterine expression of the RA-metabolizing enzyme CYP26A1 after specific time intervals (1, 4, 24, and 48 hr after treatment of ovariectomized mice). Tretinoin cytochrome P450, family 26, subfamily a, polypeptide 1 Mus musculus
3 These data indicate an additional level of hormonal control of endogenous RA levels in the mouse uterus, where its synthesis would rely on estrogen-dependent expression of RALDH enzymes, whereas its active metabolism would be triggered by progesterone-induced CYP26A1 expression. Tretinoin cytochrome P450, family 26, subfamily a, polypeptide 1 Mus musculus