Title : cis-9,trans-11-conjugated linoleic acid down-regulates phorbol ester-induced NF-kappaB activation and subsequent COX-2 expression in hairless mouse skin by targeting IkappaB kinase and PI3K-Akt.

Pub. Date : 2007 Feb

PMID : 16950795






3 Functional Relationships(s)
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1 In addition, 9Z,11E-CLA attenuated TPA-induced phosphorylation of extracellular signal-regulated protein kinase, p38 mitogen-activated protein kinase and Akt. Tetradecanoylphorbol Acetate thymoma viral proto-oncogene 1 Mus musculus
2 Co-treatment of mouse skin with the IKKbeta-specific inhibitor SC-514 (1 micromol) attenuated TPA-induced activation of Akt and NF-kappaB, and also the expression of COX-2 in hairless mouse skin. Tetradecanoylphorbol Acetate thymoma viral proto-oncogene 1 Mus musculus
3 Taken together, 9Z,11E-CLA inhibits NF-kappaB driven-COX-2 expression by blocking the IKK and PI3K-Akt signaling in TPA-treated hairless mouse skin in vivo, which may account for its previously reported anti-tumor promoting effects. Tetradecanoylphorbol Acetate thymoma viral proto-oncogene 1 Mus musculus