Title : Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide.

Pub. Date : 2006 Sep 18

PMID : 16949586






2 Functional Relationships(s)
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1 Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide. Imipramine potassium voltage-gated channel subfamily H member 1 Homo sapiens
2 The relevance of a point mutation at the C-terminal end of the S6 helix (F468) and the introduction of C-type inactivation in the blockage of hEag1 channels by astemizole, imipramine and dofetilide was tested. Imipramine potassium voltage-gated channel subfamily H member 1 Homo sapiens