Title : Transporter-mediated intestinal absorption of fexofenadine in rats.

Pub. Date : 2006 Aug

PMID : 16946558






4 Functional Relationships(s)
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1 Furthermore, uptake of fexofenadine by Xenopus oocytes expressing rat oatp3 was significantly greater than that by water-injected oocytes, and the affinity of oatp3 for fexofenadine (Km) was about 60 microM, which is comparable with the value obtained by the Ussing chamber method using rat intestinal tissues. fexofenadine solute carrier organic anion transporter family, member 1A5 Rattus norvegicus
2 Furthermore, uptake of fexofenadine by Xenopus oocytes expressing rat oatp3 was significantly greater than that by water-injected oocytes, and the affinity of oatp3 for fexofenadine (Km) was about 60 microM, which is comparable with the value obtained by the Ussing chamber method using rat intestinal tissues. fexofenadine solute carrier organic anion transporter family, member 1A5 Rattus norvegicus
3 Furthermore, uptake of fexofenadine by Xenopus oocytes expressing rat oatp3 was significantly greater than that by water-injected oocytes, and the affinity of oatp3 for fexofenadine (Km) was about 60 microM, which is comparable with the value obtained by the Ussing chamber method using rat intestinal tissues. fexofenadine solute carrier organic anion transporter family, member 1A5 Rattus norvegicus
4 These results indicate that oatp3 plays a role as an influx transporter in the intestinal absorption of fexofenadine in rats. fexofenadine solute carrier organic anion transporter family, member 1A5 Rattus norvegicus