Title : Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle.

Pub. Date : 2006 Dec

PMID : 16945991






4 Functional Relationships(s)
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1 Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle. Glucose interleukin 6 Homo sapiens
2 IL-6 increased glucose incorporation into glycogen, glucose uptake, lactate production, and fatty acid uptake and oxidation, concomitant with increased phosphorylation of AMP-activated protein kinase (AMPK), signal transducer and activator of transcription 3, and ERK1/2. Glucose interleukin 6 Homo sapiens
3 IL-6 increased glucose incorporation into glycogen, glucose uptake, lactate production, and fatty acid uptake and oxidation, concomitant with increased phosphorylation of AMP-activated protein kinase (AMPK), signal transducer and activator of transcription 3, and ERK1/2. Glucose interleukin 6 Homo sapiens
4 IL-6-mediated glucose metabolism was suppressed, but lipid metabolism was unaltered, by inhibition of PI3-kinase with LY294002. Glucose interleukin 6 Homo sapiens