Title : Neuro-endocrine interaction on lymphocytes. Testosterone-induced modulation of the lymphocyte substance P receptor.

Pub. Date : 1990 Jul

PMID : 1694535






2 Functional Relationships(s)
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Compound Name
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1 Testosterone inhibited [125I]SP binding in a dose-dependent manner with an IC50 of approximately 100 nM, while both estradiol and progesterone failed to inhibit SP binding even at concentrations as high as 1 microM. Testosterone tachykinin precursor 1 Homo sapiens
2 Furthermore, Scatchard analysis indicated that the dissociation constant (Kd) of the SP receptor was markedly increased from 0.25 nM to 2.2 nM when cells were incubated with testosterone. Testosterone tachykinin precursor 1 Homo sapiens