Pub. Date : 2006 Oct
PMID : 16944117
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: We tested the hypothesis that 5-ASA represents a substrate of P-glycoprotein (P-gp) and/or multidrug resistance-associated protein 2 (MRP2), thereby possibly contributing to variable therapeutic effects. | Mesalamine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | METHODS: We tested the hypothesis that 5-ASA represents a substrate of P-glycoprotein (P-gp) and/or multidrug resistance-associated protein 2 (MRP2), thereby possibly contributing to variable therapeutic effects. | Mesalamine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | RESULTS: In Caco-2 cells a P-gp-mediated efflux of 5-ASA (5-500 muM) could be excluded. | Mesalamine | ATP binding cassette subfamily B member 1 | Homo sapiens |