Pub. Date : 2006 Dec
PMID : 16943252
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol. | Clopidogrel | carboxylesterase 1 | Homo sapiens |
| 2 | Consistent with the tissue distribution of two carboxylesterases human carboxylesterase (HCE) 1 and HCE2, recombinant HCE1 hydrolyzed clopidogrel, whereas recombinant HCE2 hydrolyzed aspirin. | Clopidogrel | carboxylesterase 1 | Homo sapiens |
| 3 | In addition, hydrolysis of clopidogrel among liver samples was correlated well with the level of HCE1, and hydrolysis of aspirin with HCE2. | Clopidogrel | carboxylesterase 1 | Homo sapiens |