Title : Simvastatin stimulates macrophage interleukin-1beta secretion through an isoprenylation-dependent mechanism.

Pub. Date : 2007 Feb

PMID : 16942919






1 Functional Relationships(s)
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1 Simvastatin treatment did not inhibit AgLDL-induced macrophage lipid accumulation, but significantly increased the secretion of IL-1beta and IL-8 from macrophages, whilst inhibiting the secretion of tumor necrosis factor-alpha (TNF-alpha) and having no significant effect on IL-6 secretion. Simvastatin interleukin 6 Homo sapiens