Title : In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells.

Pub. Date : 2006 Nov

PMID : 16940060






2 Functional Relationships(s)
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1 The effects of ddI, but not those of AZT, on mtDNA and COII mRNA were further enhanced in the presence of TFV, a finding consistent with the inhibition of ddI clearance by TFV. Tenofovir mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 The addition of TFV to ddI or AZT appeared to slightly increase the COII mRNA/mtDNA ratio relative to that in cells treated with ddI or AZT alone. Tenofovir mitochondrially encoded cytochrome c oxidase II Homo sapiens