Pub. Date : 2006 Nov
PMID : 16938121
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histamine differentially interacts with tumor necrosis factor-alpha and thrombin in endothelial tissue factor induction: the role of c-Jun NH2-terminal kinase. | Histamine | coagulation factor II, thrombin | Homo sapiens |
| 2 | Histamine-induced p38 activation preceded a weak second activation to both TNF-alpha and thrombin. | Histamine | coagulation factor II, thrombin | Homo sapiens |
| 3 | Histamine-induced c-Jun NH2-terminal kinase (JNK) activation was followed by a strong second activation to TNF-alpha, and less to thrombin. | Histamine | coagulation factor II, thrombin | Homo sapiens |
| 4 | Histamine augmented TNF-alpha- and thrombin-induced vascular cell adhesion molecule 1 (VCAM-1) expression to a similar extent. | Histamine | coagulation factor II, thrombin | Homo sapiens |
| 5 | CONCLUSIONS: Histamine differentially augments TNF-alpha- vs. thrombin-induced TF expression and activity, which is mediated by the H1-receptor, occurs at the mRNA level, and is related to differential JNK activation. | Histamine | coagulation factor II, thrombin | Homo sapiens |