Title : Prolonged exposure of colon cancer cells to the epidermal growth factor receptor inhibitor gefitinib (Iressa(TM)) and to the antiangiogenic agent ZD6474: Cytotoxic and biomolecular effects.

Pub. Date : 2006 Aug 28

PMID : 16937523






1 Functional Relationships(s)
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1 Treatment with gefitinib or ZD6474 also inhibited the expression of EGFR downstream signal molecules, p-Erk1/2 and p-Akt, although the magnitude of these effects varied between treatments and cell lines. Gefitinib mitogen-activated protein kinase 3 Homo sapiens