Title : The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: relationship to clinical effects in mood disorders.

Pub. Date : 2007 Apr

PMID : 16936714






3 Functional Relationships(s)
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1 Chronic treatment with the antimanic agents, lithium and valproate, resulted in reduced synaptic expression of the AMPA(-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor subunit GluR1 in the hippocampus, while treatment with an antidepressant (imipramine) enhanced the synaptic expression of GluR1. Imipramine glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens
2 In addition, lamotrigine and riluzole, as well as the traditional antidepressant imipramine, also increased GluR1 phosphorylation at GluR1 (S845) in the hippocampus after chronic in vivo treatment. Imipramine glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens
3 In addition, lamotrigine and riluzole, as well as the traditional antidepressant imipramine, also increased GluR1 phosphorylation at GluR1 (S845) in the hippocampus after chronic in vivo treatment. Imipramine glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens