Title : The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: relationship to clinical effects in mood disorders.

Pub. Date : 2007 Apr

PMID : 16936714






2 Functional Relationships(s)
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1 We found that the agents with a predominantly antidepressant profile, namely lamotrigine and riluzole, significantly enhanced the surface expression of GluR1 and GluR2 in a time- and dose-dependent manner in cultured hippocampal neurons. Lamotrigine glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens
2 Concomitant with the GluR1 and GluR2 changes, the peak value of depolarized membrane potential evoked by AMPA was significantly higher in lamotrigine- and riluzole-treated neurons, supporting the surface receptor changes. Lamotrigine glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens