Pub. Date : 2007 Apr
PMID : 16936714
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that the agents with a predominantly antidepressant profile, namely lamotrigine and riluzole, significantly enhanced the surface expression of GluR1 and GluR2 in a time- and dose-dependent manner in cultured hippocampal neurons. | Lamotrigine | glutamate ionotropic receptor AMPA type subunit 1 | Homo sapiens |
| 2 | Concomitant with the GluR1 and GluR2 changes, the peak value of depolarized membrane potential evoked by AMPA was significantly higher in lamotrigine- and riluzole-treated neurons, supporting the surface receptor changes. | Lamotrigine | glutamate ionotropic receptor AMPA type subunit 1 | Homo sapiens |
| 3 | Phosphorylation of GluR1 at the PKA (cAMP-dependent protein kinase) site (S845) was enhanced in both lamotrigine- and riluzole-treated hippocampal neurons, but reduced in valproate-treated neurons. | Lamotrigine | glutamate ionotropic receptor AMPA type subunit 1 | Homo sapiens |
| 4 | In addition, lamotrigine and riluzole, as well as the traditional antidepressant imipramine, also increased GluR1 phosphorylation at GluR1 (S845) in the hippocampus after chronic in vivo treatment. | Lamotrigine | glutamate ionotropic receptor AMPA type subunit 1 | Homo sapiens |
| 5 | In addition, lamotrigine and riluzole, as well as the traditional antidepressant imipramine, also increased GluR1 phosphorylation at GluR1 (S845) in the hippocampus after chronic in vivo treatment. | Lamotrigine | glutamate ionotropic receptor AMPA type subunit 1 | Homo sapiens |