Title : Characterisation of a P140K mutant O6-methylguanine-DNA-methyltransferase (MGMT)-expressing transgenic mouse line with drug-selectable bone marrow.

Pub. Date : 2006 Sep

PMID : 16927363






2 Functional Relationships(s)
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1 RESULTS: Expression of the transgene provided chemoprotection and allowed in vivo selection of MGMT(P140K)-expressing cells in transgenic mice after exposure to O6-benzylguanine (BG) and N,N"-bis(2-chloroethyl)-N-nitrosourea (BCNU). O(6)-benzylguanine O-6-methylguanine-DNA methyltransferase Mus musculus
2 RESULTS: Expression of the transgene provided chemoprotection and allowed in vivo selection of MGMT(P140K)-expressing cells in transgenic mice after exposure to O6-benzylguanine (BG) and N,N"-bis(2-chloroethyl)-N-nitrosourea (BCNU). O(6)-benzylguanine O-6-methylguanine-DNA methyltransferase Mus musculus