Title : JWA is required for the antiproliferative and pro-apoptotic effects of all-trans retinoic acid in Hela cells.

Pub. Date : 2006 Sep

PMID : 16922813






2 Functional Relationships(s)
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1 Western blot analysis revealed that ATRA caused increased expression of JWA in HeLa cells in a dose- and time-dependent manner, accompanied by activation of extracellular signal-regulated kinase (ERK) 1/2 phosphorylation. Tretinoin mitogen-activated protein kinase 3 Homo sapiens
2 However, ERK1/2 phosphorylation induced by ATRA was inhibited in JWA-deficient HeLa cells. Tretinoin mitogen-activated protein kinase 3 Homo sapiens