Pub. Date : 2006 Oct 10
PMID : 16920098
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Histamine and amthamine, a selective histamine H(2)-receptor agonist, concentration-dependently decreased myogenic tone, which was unchanged in the absence of endothelium. | Histamine | histamine receptor H 2 | Rattus norvegicus |
2 | The dilation to histamine was antagonized by tiotidine, a selective antagonist of histamine H(2)-receptor subtype, giving a pK(B) of 7.86 that was not altered in the absence of endothelium. | Histamine | histamine receptor H 2 | Rattus norvegicus |
3 | These results suggest that histamine-mediated reversal of myogenic tone in rat cerebral arteries is endothelium-independent, mediated by histamine H(2)-receptor subtype with no involvement of guanylyl cyclase or adenylyl cyclase activation and most likely involves activation of K(V) potassium channels. | Histamine | histamine receptor H 2 | Rattus norvegicus |