Title : Sivelestat, a specific neutrophil elastase inhibitor, suppresses the growth of gastric carcinoma cells by preventing the release of transforming growth factor-alpha.

Pub. Date : 2006 Oct

PMID : 16918998






2 Functional Relationships(s)
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1 Interestingly, sivelestat significantly reduced NE-induced EGFR phosphorylation and ERK1/2 activation and completely blocked the release of TGF-alpha from the TMK-1 cell surface. sivelestat transforming growth factor alpha Homo sapiens
2 These results indicate that sivelestat suppresses the growth of gastric cancer cells by inhibiting the release of TGF-alpha stimulated by NE, which often occurs after surgical stresses. sivelestat transforming growth factor alpha Homo sapiens