Pub. Date : 2006 Aug
PMID : 16918719
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lidocaine is metabolized by cytochrome P450 3A4 (CYP3A4) and CYP1A2 enzymes, but inhibitors of CYP3A4 have had only a minor effect on its pharmacokinetics. | Lidocaine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Lidocaine is metabolized by cytochrome P450 3A4 (CYP3A4) and CYP1A2 enzymes, but inhibitors of CYP3A4 have had only a minor effect on its pharmacokinetics. | Lidocaine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Lidocaine is metabolized by cytochrome P450 3A4 (CYP3A4) and CYP1A2 enzymes, but inhibitors of CYP3A4 have had only a minor effect on its pharmacokinetics. | Lidocaine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | We studied the effect of co-administration of fluvoxamine (CYP1A2 inhibitor) and erythromycin (CYP3A4 inhibitor) on the pharmacokinetics of lidocaine in a double-blind, randomized, three-way cross-over study. | Lidocaine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | The concomitant use of both fluvoxamine and a CYP3A4 inhibitor like erythromycin may further increase plasma lidocaine concentrations. | Lidocaine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |