Pub. Date : 2006
PMID : 16914897
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: ATP, 2-meSATP, UTP and UDP cause a rapid and transitory increase in the phosphorylation of MAPK/ERK. | Adenosine Triphosphate | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | ATP-dependent activation of MAPK/ERK was prevented by pretreatment of HUVEC with pertussis toxin or MEK inhibitor PD98059. | Adenosine Triphosphate | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | In addition, activation of the MAPK/ ERK cascade by ATP was blocked in cells pretreated with wortmannin and LY294002, but not by U73122, BAPTA or a Ca(2+)-free medium. | Adenosine Triphosphate | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Furthermore, an inhibition of ATP-dependent MAPK/ERK phosphorylation was observed in HUVEC pretreated with high doses of GF109203X or myristoylated PKC- zeta pseudosubstrate. | Adenosine Triphosphate | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | However, ATP-stimulated MAPK/ERK activation was unaffected in cells pretreated with AG1478 or perillic acid. | Adenosine Triphosphate | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | CONCLUSION: These observations suggest that the effects mediated by ATP in HUVEC occur via PTX-sensitive G-protein-coupled P2Y receptors through PI3K-dependent mechanisms, in which PDK1 and PKC-zeta are two key molecules within signal cascade leading to MAPK/ERK activation. | Adenosine Triphosphate | mitogen-activated protein kinase 1 | Homo sapiens |