Title : Scaffolding protein INAD regulates deactivation of vision by promoting phosphorylation of transient receptor potential by eye protein kinase C in Drosophila.

Pub. Date : 2006 Aug 16

PMID : 16914683






4 Functional Relationships(s)
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1 Moreover, deactivation is regulated by the interaction between INAD and TRP, because abrogation of this interaction in InaD(p215) results in slow deactivation similar to that of inaC(p209) lacking eye-PKC. Tryptophan inactivation no afterpotential D Drosophila melanogaster
2 Moreover, deactivation is regulated by the interaction between INAD and TRP, because abrogation of this interaction in InaD(p215) results in slow deactivation similar to that of inaC(p209) lacking eye-PKC. Tryptophan inactivation no afterpotential D Drosophila melanogaster
3 To elucidate the mechanisms whereby eye-PKC modulates deactivation, here we demonstrate that eye-PKC, via tethering to INAD, phosphorylates TRP in vitro. Tryptophan inactivation no afterpotential D Drosophila melanogaster
4 Furthermore, transgenic expression of modified TRP bearing an Ala substitution leads to slow deactivation of the visual response similar to that of InaD(p215). Tryptophan inactivation no afterpotential D Drosophila melanogaster