Title : Design and discovery of a novel dipeptidyl-peptidase IV (CD26)-based prodrug approach.

Pub. Date : 2006 Aug 24

PMID : 16913724






3 Functional Relationships(s)
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1 Here we describe a novel type of enzyme-based prodrug approach in which a dipeptide moiety is linked to a nonpeptidic therapeutic drug through an amide bond which is specifically cleaved by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme activity present in plasma and on the surface of certain cells. Amides dipeptidyl peptidase 4 Homo sapiens
2 Here we describe a novel type of enzyme-based prodrug approach in which a dipeptide moiety is linked to a nonpeptidic therapeutic drug through an amide bond which is specifically cleaved by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme activity present in plasma and on the surface of certain cells. Amides dipeptidyl peptidase 4 Homo sapiens
3 Here we describe a novel type of enzyme-based prodrug approach in which a dipeptide moiety is linked to a nonpeptidic therapeutic drug through an amide bond which is specifically cleaved by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme activity present in plasma and on the surface of certain cells. Amides dipeptidyl peptidase 4 Homo sapiens