Pub. Date : 2006 Sep-Oct
PMID : 16912660
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Moreover, raloxifene treatment significantly reduced IGF-1 and increased IGFBP-3 and SHBG plasma levels at 24 months. | Raloxifene Hydrochloride | insulin like growth factor 1 | Homo sapiens |
| 2 | Such an effect could perhaps explain the reduction in the incidence of mammary carcinoma observed in the Multiple Outcomes of Raloxifene Evaluation study probably due to the direct antiestrogenic activity of raloxifene on mammalian tissue and/or its indirect activity increasing SHBG levels or modifying the IGF-1/IGFBP-3 ratio. | Raloxifene Hydrochloride | insulin like growth factor 1 | Homo sapiens |