Title : Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase.

Pub. Date : 2007 Apr 20

PMID : 16904809






5 Functional Relationships(s)
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1 OP inhibit acetylcholinesterase (AChE) and therefore standard treatment of respective poisoning includes AChE reactivators (oximes) in combination with antimuscarinic agents. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Recently, we studied the reactivating potency of several oximes with human AChE inhibited by structurally different OP and observed remarkable differences depending on the OP and oxime. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens
3 Recently, we studied the reactivating potency of several oximes with human AChE inhibited by structurally different OP and observed remarkable differences depending on the OP and oxime. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens
4 In contrast, no structure-activity dependence could be observed for the oxime-induced reactivation of AChE and BChE inhibited by the compounds tested. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens
5 In general, OP-inhibited AChE and BChE were susceptible towards reactivation by oximes. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens